A missile struck the U.S. Embassy compound in Baghdad’s heavily fortified Green Zone on Saturday, raising alarm about the spreading regional spillover of the conflict between the United States and Iran into Iraqi territory and endangering the diplomatic mission at the heart of American operations in the country.

No casualties were immediately confirmed, and U.S. officials said the compound’s hardened structures and blast barriers had limited the physical damage. However, the strike on the embassy itself — as opposed to surrounding military facilities that had been targeted repeatedly in recent weeks — represented a significant escalation in the targeting of American presence in Iraq.

The origin of the missile was under investigation, with American officials declining to immediately attribute responsibility. However, Iraqi resistance factions aligned with Iran, including Kata’ib Hezbollah and Harakat al-Nujaba, had claimed responsibility for dozens of attacks on U.S. facilities in Iraq since the conflict began on February 28.

The Iraqi government condemned the attack in a statement from the prime minister’s office, calling it a dangerous act that threatened Iraq’s sovereignty and its diplomatic relationship with the United States. Baghdad has been caught in an increasingly untenable position, hosting American forces and diplomatic personnel while also maintaining working relations with Iran and affiliated militia groups.

The State Department ordered non-essential personnel at the embassy to shelter in place and activated emergency protocols. American diplomatic staff had been operating under heightened security conditions since the start of the conflict, with many personnel relocated to secure facilities within the compound.

Senators and representatives in Washington called for a stronger protective posture around American diplomatic facilities in the region. Several lawmakers argued that the embassy should be temporarily relocated to a more secure location given the frequency of attacks on the Green Zone.

The U.S. military said it was assessing the situation and that force protection measures at all facilities in Iraq had been reviewed and reinforced following recent incidents. Additional air defense assets had been positioned around the embassy precinct in recent days.

For the Iraqi government, the embassy strike deepened a painful dilemma. Pressure from Iran-aligned political factions within the Iraqi parliament had intensified calls for the expulsion of American forces from the country, while the government’s security forces remained dependent on American support to manage ongoing threats from remnants of the Islamic State.

The attack came on the same day that Iranian drones struck American facilities in Saudi Arabia and the UAE port of Fujairah, suggesting a coordinated campaign to impose costs across the full range of American regional presence simultaneously. Military analysts noted the synchronization of the attacks as evidence of Iranian strategic planning rather than opportunistic strikes.

American officials said they were assessing the attack and evaluating appropriate responses. The White House stated that any attack on a U.S. Embassy constituted an attack on American sovereign territory and that the administration would take whatever steps were necessary to protect its personnel and missions abroad.